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Spectroscopic Evaluation of Novel Tacrine- Coumarin Hybrids as HSA-Interacting Agents

Author

Listed:
  • Eva Konkoľová

    (Department of Biochemistry, Faculty of Science, P J Šafárik University, Slovak Republic)

  • Monika HudaÄ ová

    (Department of Organic Chemistry, Faculty of Science, P J Šafárik University, Slovak Republic)

  • Slávka Hamuľaková
  • Mária Kožurková

    (Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic)

Abstract

In this work, we investigated the human serum albumin binding behavior of a series of novel derivatives with both tacrine and coumarin pharmacophores. The compounds were investigated using UV-Vis absorption and fluorescence spectroscopy. KB values were found to be in order of 103 M-1. The values of n indicate that only one independent class of binding sites is available for tacrine-coumarin hybrids on HSA. Synchronous fluorescence spectra showed that compounds did not have any noticeably effect on α-helical conformation of HSA. Our data indicated that these tacrine-coumarin molecules exhibit promising potential which would be of considerable use in the development of drugs with enhanced or more selective effects and greater clinical efficacy

Suggested Citation

  • Eva Konkoľová & Monika HudaÄ ová & Slávka Hamuľaková & Mária Kožurková, 2019. "Spectroscopic Evaluation of Novel Tacrine- Coumarin Hybrids as HSA-Interacting Agents," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(2), pages 36-42, February.
    • Handle: RePEc:adp:jomcij:v:8:y:2019:i:2:p:36-42
    DOI: 10.19080/OMCIJ.2019.08.555733
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