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Potentiometric Determination of Asenapine Maleate Using PVC Membrane and Carbon Paste Ion-selective Electrodes

Author

Listed:
  • Nesrin K Ramadan
  • Azza A Moustafa

    (Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Egypt)

  • Taghreed A Mohamed
  • Rowayda M Fouad

    (Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, Egypt)

Abstract

Three sensitive and selective electrodes were developed for the determination of asenapine mallet. One electrode containing PVC membrane, ammomium renikate as an anion exchanger and dibutyl phthalate as a plasticizer (sensor I). Two carbon past ISE using phosphodiester acid and ammomium renikate as an anion exchanger (sensors II and III) and dibutyl phthalate as a plasticizer. The proposed electrodes showed a near-sensation response in the range from 1.00×10-5 to 1.00×10-2 mol/L for sensor I and 5.00×10-5 to 1.00×10-2 mol/L for both sensor II and III. The selectivity of the proposed electrodes to a number of interferences was investigated. Asenapine was successfully determined in pure form, pharmaceutical formulation and in presence of its oxidative degradation product.

Suggested Citation

  • Nesrin K Ramadan & Azza A Moustafa & Taghreed A Mohamed & Rowayda M Fouad, 2018. "Potentiometric Determination of Asenapine Maleate Using PVC Membrane and Carbon Paste Ion-selective Electrodes," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 8(1), pages 1-10, September.
    • Handle: RePEc:adp:jomcij:v:8:y:2018:i:1:p:1-10
    DOI: 10.19080/OMCIJ.2018.08.555726
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