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Efficient Synthesis of Anti-depressant Agent Agomelatine

Author

Listed:
  • J Kranthi Kumar
  • Siva Ganesh Narala
  • A Venkat Narsaiah

    (Department of Fluoro-Agro Chemicals, Organic Synthesis Laboratory, India)

Abstract

A simple and efficient synthesis of anti-depressant agent Agomelatine has been achieved in 5 steps with an overall yield 63%. The synthesis was started from commercially available starting material, ethyl-2(7-methoxynaphthalen-1-yl)-acetate (2). All the reactions are very clean and yield excellent.

Suggested Citation

  • J Kranthi Kumar & Siva Ganesh Narala & A Venkat Narsaiah, 2018. "Efficient Synthesis of Anti-depressant Agent Agomelatine," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 7(3), pages 103-106, July.
    • Handle: RePEc:adp:jomcij:v:7:y:2018:i:3:p:103-106
    DOI: 10.19080/OMCIJ.2018.07.555715
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