IDEAS home Printed from https://ideas.repec.org/a/adp/jomcij/v5y2018i5p155-159.html
   My bibliography  Save this article

Synthesis of Sildenafil Citrate Validated HPLC Method and Its Pharmaceutical Dosage Forms

Author

Listed:
  • Krishna Sarma Pathy
  • Sriraman Chakaravathy

    (Department of Chemistry, IPL research center Lucknow, sriramanchakravarthy, Consultant API, vadodara, india)

Abstract

The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 1998. It is a potent and selective inhibitor of cGMP specific Phosphodiesterase Type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP. Sildenafil has a peripheral site of action on erections. This substance has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of nitric oxide on this tissue. However, there is no analytical method for determination of this active compound in pharmaceutical preparations in the current European and US Pharmacopoeia. The aim of this study was to develop and validate HPLC method for sildenafil analysis in pharmaceutical dosage forms.

Suggested Citation

  • Krishna Sarma Pathy & Sriraman Chakaravathy, 2018. "Synthesis of Sildenafil Citrate Validated HPLC Method and Its Pharmaceutical Dosage Forms," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 5(5), pages 155-159, March.
    • Handle: RePEc:adp:jomcij:v:5:y:2018:i:5:p:155-159
    DOI: 10.19080/OMCIJ.2018.05.555674
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555674.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555674.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/OMCIJ.2018.05.555674?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:jomcij:v:5:y:2018:i:5:p:155-159. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.