Synthesis, Characterization, Thermodynamic and Biological Activity Studies for New Complexes of Some Transition Metals and Zinc With Schiff’s Bases [2,5di (1-Thi-Ophen-2-yl-Ethylidene)-Hydrazine) 1, 3, 4-Thiadiazole]

New metal complexes of type [M (L)] Cl2, [M (L) Cl2] [(M = Co (II), Ni (II), Cu (II) and Zn (II)] were prepared using the ligand (L) =[2,5di (1-thiophen-2-yl-ethylidene)-hydrazine) 1,3,4-thiadiazole]. The Schiff bases were condensed from [2-acetylthiophene] with [2,5-dihydrazino-1,3,4-thiadiazole] in alcoholic medium. The Schiff bases were tetra dentate ligand that were used for complexion with Co2+, Ni2+, Cu2+ and Zn2+ ions. The prepared complexes were characterized by FTIR, UV-vis as well as magnetic susceptibility, conductivity measurements, atomic absorption, and thermal analysis & Schiff bases characterized by FTIR, UV-vis, 1H-NMR and LC mass spectra and, thermal analysis. The activation thermodynamic parameters, such as ΔE*, ΔH*, ΔS* and ΔG* are calculated from the TGA curve using Coats-Red fern method. From the spectral measurements, structures for the complexes were proposed. Preliminary in vitro tests for antimicrobial activity show that all prepared compounds display good activity to Staphylococcus aureus, Escherishia coli, Pseudononas aeroginosa and Cndida albicans.