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Multi Component Green Synthesis of Bis-Pyrrol Indoline-2-Ones Triazoles Catalysed By Cu NPS on Activated Carbon in Water

Author

Listed:
  • B Saritha
  • P Venkata Ramana
  • D Madhavi
  • LK Ravindranath

    (Department of Chemistry, Sri Krishnadevaraya University, India)

Abstract

A variety of potentially biological active multi component green synthesis of Bis-pyrrol indoline-2-ones triazoles possessing N- alkyl furan/ N- alkyl thiophene /N- alkyl pyrrol by catalysed Cu-NPs on activated carbon in water involving green synthetic technology have been developed. It involves in three steps. The first step involves the synthesis of 1-prop-2-ynyl indoline-2,3-dione(3) from indoline -2,3-dione and 3-chloropropanone(2). The intermediate1-prop-2-ynyl indoline-2,3-dione(3) was converted into 1-((1-furan/thiophene/pyrrol/phenyl/4-methyl phenyl/4-fluoro phenyl/4- trifluro methyl phenyl/4-nitro phenyl)-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)indiline-2,3-dione (5a-h) by 1,3-dipolar cyclo addition with 2-bromo methyl-1H-furan/ 2-bromo methyl-1H-thiophene/ 2-bromo methyl-1H-pyrrol benzyl bromide/4-methyl benzyl bromide/4-fluoro benzyl bromide/4-tri fluoro benzyl bromide/4- nitro benzyl bromide (4a-h) catalysed by Cu-NPs on activated carbon catalysed click reaction in neat water depicted in step-2.

Suggested Citation

  • B Saritha & P Venkata Ramana & D Madhavi & LK Ravindranath, 2017. "Multi Component Green Synthesis of Bis-Pyrrol Indoline-2-Ones Triazoles Catalysed By Cu NPS on Activated Carbon in Water," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 4(1), pages 14-21, October.
    • Handle: RePEc:adp:jomcij:v:4:y:2017:i:1:p:14-21
    DOI: 10.19080/OMCIJ.2017.04.555630
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