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Design, Synthesis of Novel Thieno [2,3-d] derivatives and their Anti-Microbial studies

Author

Listed:
  • Virupakshi Prabhakar

    (Faculty of Chemistry, Rgukt-Iiit Ongole, India)

  • Kondra Sudhakar Babu
  • LK Ravindranath

    (Department of Chemistry, Sri Krishnadevaraya University, India)

  • VM Dayalan

    (Faculty of Engineering Chemistry, Jawaharlal Nehru Technological University-Anantapuramu (JNTU-A), India)

Abstract

A new series of 4-Substituted/Heterocyclic -N-(4-(4-(trifluoromethyl/Nitro)phenoxy)thieno[2,3-d]pyrimidin-2-yl)benzamide (8 a-j) derivatives were synthesized by a five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. Several Thieno [2,3-d] Pyrimidines have been prepared from methyl 2-aminothiophene-3-carboxylate(1).The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) from Gram positive group of bacteria. Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria. Anti-fungal activity against Aspergillus Niger (A. Niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin & Flucanazole. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 8j, 8i, 8h and 8g possess good activity.

Suggested Citation

  • Virupakshi Prabhakar & Kondra Sudhakar Babu & LK Ravindranath & VM Dayalan, 2017. "Design, Synthesis of Novel Thieno [2,3-d] derivatives and their Anti-Microbial studies," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 3(4), pages 91-102, September.
    • Handle: RePEc:adp:jomcij:v:3:y:2017:i:4:p:91-102
    DOI: 10.19080/OMCIJ.2017.03.555618
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