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N- and / or O- Alkylation of Quinazolinone Derivatives

Author

Listed:
  • Anton V Kolotaev

    (The Federal State Unitary Enterprise, Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre, Kurchatov Institute, Russia)

  • Vasiliy N Osipov

    (National Research Centre, Kurchatov Institute, Russia)

  • Karine R Matevosyan

    (N N Blokhin National Medical Research Center of Oncology, Russia)

  • Eugene A Bondarenko
  • Arthur R Mavlianberdiev
  • Derenik S Khachatryan

    (Mendeleev University of Chemical Technology of Russia, Russia)

Abstract

Here we report on a strategy based on the capabilities of 2D NMR spectroscopy, which focuses on determining the exact structures of promising HDAC / VEGF-2 inhibitors and intermediate N- or O-alkylated building blocks for their construction. Due to which, in contrast to the erroneous conclusions of other studies, it has been unequivocally established that quinazolin-4-ones with alkyl halides under the classical conditions of two-phase catalysis: the solid phase (alkali metal carbonates) and liquid (aprotic solvents) are subjected to alkylation in the 3-N- position.

Suggested Citation

  • Anton V Kolotaev & Vasiliy N Osipov & Karine R Matevosyan & Eugene A Bondarenko & Arthur R Mavlianberdiev & Derenik S Khachatryan, 2020. "N- and / or O- Alkylation of Quinazolinone Derivatives," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 10(2), pages 30-37, November.
    • Handle: RePEc:adp:jomcij:v:10:y:2020:i:2:p:30-37
    DOI: 10.19080/OMCIJ.2020.10.555781
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