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Post-Traumatic Epilepsy: Incidence and Mechanisms after Brain Injury

Author

Listed:
  • Timothy Van Meter

    (Program for Neurological Diseases, ImmunArray Inc., USA)

  • Anil Kumar

    (Department of Neurology, Great Plains Health, USA)

Abstract

Post-traumatic epilepsy can result from traumatic brain injury (TBI) due to a number immediate and chronic changes to the cellular environment in the affected tissues. This form of acquired epilepsy represents 20% of symptomatic epilepsy cases and relates to injury severity. The pathological mechanisms occurring after TBI that give rise to seizure initiation include an early phase (early PTE 1-7 days post-injury) and a late phase which can occur months to years after TBI. The pathological mechanisms at early and late onset PTE differ, and are still poorly understood. Underlying mechanisms are reviewed in the context of epileptogenesis, and prophylactic use of medications is briefly reviewed for both pediatric and adult patients in relation to outcomes. PTE is a concerning adverse health outcome as a consequence of TBI, and should be assessed and monitored with newer advances in bedside point of care technologies. Technologies such as blood biomarker tests and portable EEG devices hold promise for diagnosing and even predicting PTE.

Suggested Citation

  • Timothy Van Meter & Anil Kumar, 2018. "Post-Traumatic Epilepsy: Incidence and Mechanisms after Brain Injury," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 8(1), pages 1-3, May.
    • Handle: RePEc:adp:joajnn:v:8:y:2018:i:1:p:1-3
    DOI: 10.19080/OAJNN.2018.08.555726
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