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How to Define Neuroprotection: The Case of Phenytoin

Author

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  • Keppel Hesselink JM

    (University of Witten-Herdecke, Germany)

Abstract

Phenytoin is recently rediscovered as a neuroprotective compound due to the positive results on structural endpoints in a clinical trial in optic neuritis in multiple sclerosis patients. Data supporting its neuroprotective properties however originated already in the 30s of last century. The relation between anticonvulsants, the protection of brain tissue and the influence of lack of oxygen on nervous tissue was conceptualized 80 years ago. The concepts ‘protection’ and ‘neuroprotection’ have been defined in various of ways and phenytoin was one of the first compounds linked to this concept. However, anno 2018 there still are no neuroprotective compounds registered and available in the clinic. Furthermore, its seems that there is no consensus on definitions for ‘neuroprotection’. We discuss literature on the neuro-protective properties of phenytoin and analyze the various approaches and definitions of the concept neuroprotection.

Suggested Citation

  • Keppel Hesselink JM, 2018. "How to Define Neuroprotection: The Case of Phenytoin," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 7(4), pages 83-87, May.
    • Handle: RePEc:adp:joajnn:v:7:y:2018:i:4:p:83-87
    DOI: 10.19080/OAJNN.2018.07.555719
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