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In Search of an Animal Model of Autism Spectrum Disorders

Author

Listed:
  • Janusz W BÅ‚aszczyk

    (Jerzy Kukuczka Academy of Physical Education, Poland)

  • Bogdan Sadowski

    (Institute for Genetics and Animal Breeding, Polish Academy of Sciences, Poland)

  • Jacek PolechoÅ„ski

    (Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education, Poland)

Abstract

In search of an animal model of autism spectrum disorders, the acoustic startle response elicited by 110 dB 10-ms pulses was studied at different periods of animal development in mouse lines selectively bred for high (HA) and low (LA) swim analgesia. Animals used in this study were obtained from our colony of Swiss-Webster mice selectively bred throughout 56-59 generations for the magnitude of analgesia. ASRs were assessed in 240 mice (both males and females), exposed to a sequence of twenty 10ms white noise pulses (10 ms, 110 dB SPL) presented in random order, at 70 dB white noise background. Mice from four successive generations were studied only once at the postnatal day P30, P60, P90, and P120 respectively for each generation. Statistical analysis revealed significant differences between HA, LA, and control (C) animals. From the second month of life, the ASR amplitudes differed between the mouse lines in the order of HA > Control > LA. Within all lines studied the male subjects startled more than the females. The differences may be accounted for the traits obtained during selective bred and the HA line can be recommended as a model for autism spectrum disorders.

Suggested Citation

  • Janusz W BÅ‚aszczyk & Bogdan Sadowski & Jacek PolechoÅ„ski, 2020. "In Search of an Animal Model of Autism Spectrum Disorders," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 13(3), pages 48-52, April.
    • Handle: RePEc:adp:joajnn:v:13:y:2020:i:3:p:48-52
    DOI: 10.19080/OAJNN.2020.13.555863
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