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Neurological Manifestations of Cobalamin Deficiency

Author

Listed:
  • Ammouri
  • Harmouche H
  • Khibri
  • Maamar M
  • Mezalek Tazi Z
  • Adnaoui M

    (Department of Internal medicine, University Mohamed V of medicine, Morocco)

  • Benkirane S
  • Azlarab M

    (Laboratoire central d’hématologie, University Mohamed V of medicine, Morocco)

  • Mouatassim N

    (Department of Radiology, University Mohamed V of medicine, Morocco)

Abstract

Vitamin B12 (cobalamin) is synthesized by microorganisms and detected in trace amounts mostly in foods of animal origin. The absorption and transporting mechanisms depended on three key proteins: haptocorrin, intrinsic factor and transcobalamin. On the peripherу cobalamin circulates only in binding with proteins transcobalamin I and II (holotranscobalamin). Holotranscobalamin is absorbed by different cells, whereas transcobalamin I-binded vitamin B12 - only by liver and kidneys. Two forms of cobalamin were identified as coenzymes of cellular reactions which are methylcobalamin and hydroxyadenosylcobalamin. The interaction between folate and B12 is responsible for the megaloblastic anemia seen in both vitamin deficiencies. Vitamin B 12 is necessary for the development and initial myelination of the central nervous system as well as for the maintenance of its normal function.

Suggested Citation

  • Ammouri & Harmouche H & Khibri & Maamar M & Mezalek Tazi Z & Adnaoui M & Benkirane S & Azlarab M & Mouatassim N, 2019. "Neurological Manifestations of Cobalamin Deficiency," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 12(2), pages 50-58, December.
    • Handle: RePEc:adp:joajnn:v:12:y:2019:i:2:p:50-58
    DOI: 10.19080/OAJNN.2019.12.555834
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