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Anti-GAD Cerebellar Ataxia Associated with Neuroendocrine Pancreatic Tumor, Diagnostic and Therapeutic Approach

Author

Listed:
  • Anfal Al Raisi
  • Sultan Al Mazroui

    (Oman Medical specialty board, GFP program, Oman)

  • Ahmed Sameer Nadeem
  • Abdullah AL Salti

    (Department of Neurology, Khoula Hospital-MOH, Oman)

Abstract

Anti- Glutamic Acid Decarboxylase antibodies (anti-GAD Abs) associated Cerebellar Ataxia (CA) is one of the rare neurologic conditions that affect the central nervous system and has been linked to autoimmune endocrine disorders or associated with paraneoplastic tumors [1-3]. Here we report a case of a 37 years old Omani woman, presented with symptoms of subacute cerebellar ataxia, with high serum levels of anti-Glutamic acid decarboxylase antibodies which suggests the diagnosis of Anti- Glutamic acid decarboxylase antibodies cerebellar ataxia. Since there are no approved international guidelines for the treatment of immune-mediated anti-GAD cerebellar ataxia and the management is case dependent [4], we used a trial of combination of maintenance therapies, after induction with a 5 days course of mehylpredinisolon and tapering, including monthly IV Immunoglobulin, followed by adding a course of Rituximab and daily Azathioprine for 12 months, which lead to symptomatic improvement.

Suggested Citation

  • Anfal Al Raisi & Sultan Al Mazroui & Ahmed Sameer Nadeem & Abdullah AL Salti, 2019. "Anti-GAD Cerebellar Ataxia Associated with Neuroendocrine Pancreatic Tumor, Diagnostic and Therapeutic Approach," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 12(1), pages 8-12, November.
    • Handle: RePEc:adp:joajnn:v:12:y:2019:i:1:p:8-12
    DOI: 10.19080/OAJNN.2019.12.555828
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