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The Role of Botulinum Injection in Parkinson’s Disease

Author

Listed:
  • Qamar Zaman
  • Muhammad Farhan Khan

    (Department of Neurology, Shifa International Hospital, Shifa Tameer-e-milat university, Pakistan)

Abstract

Botulinum toxin inhibits the release of acetylcholine at the neuromuscular junction, there by blocking neuromuscular conduction and muscle contraction. The mechanism of action of its various serotypes, are similar in respect that all of them cleave the SNARE proteins. It has been successfully used to treat a variety of symptoms related to Parkinson’s disease including cervical dystonia, foot dystonia, focal hand dystonia, laryngeal dystonia, oromandibular dystonia, blepharospasm, lid apraxia, camptocormia, hand and jaw tremor, sialorrhea, hyperhidrosis, dysphagia, constipation, and overactive bladder. We did the review of the literature to find out the benefit observed with it, units used, and muscle selected for different indications in various studies done. This might help to determine the important issues related to Parkinson’s disease where its application may be beneficial and also to pave a way for future recommendations.

Suggested Citation

  • Qamar Zaman & Muhammad Farhan Khan, 2019. "The Role of Botulinum Injection in Parkinson’s Disease," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 10(4), pages 70-72, March.
    • Handle: RePEc:adp:joajnn:v:10:y:2019:i:4:p:70-72
    DOI: 10.19080/OAJNN.2019.10.555792
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