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Successful Treatment of Disseminated Fungal Infections in three Pediatric Patients with Acute Lymphoblastic Leukemia

Author

Listed:
  • Funda TekkeÅŸin1
  • Zühre Kaya
  • Ãœlker Koçak
  • Ä°dil Yenicesu

    (Department of Pediatric Hematology, Gazi University, Turkey)

  • EmineBetül Derinkuyu

    (Department of Pediatric Radiology, Gazi University, Turkey)

  • Alp Özgün Börcek

    (Department of Neurosurgery, Gazi University, Turkey)

  • BurcuCeylanCura Yayla
  • Hasan Tezer

    (Department of Pediatric Infectious Diseases, Gazi University, Turkey)

  • AyÅŸe Kalkanci

    (Department of Microbiology, Gazi University, Turkey)

  • Alper Ceylan

    (Department of Otorhinolaryngology, Gazi University, Turkey)

Abstract

We present the cases of three children with acute lymphoblastic leukemia (ALL) who developed disseminated invasive fungal infections (IFIs) (Aspergillus spp. n=1, Candida spp. n=2). All were successfully treated with antifungal drugs and ancillary treatments; however, in two cases, leukemic cells were not eradicated by chemotherapy before transplantation. It has been noted that, despite the success of novel antifungal drugs in patients with ALL, long-lasting IFIs during chemotherapy may negatively affect leukemia prognosis. We emphasize the need for guidelines to provide assistance in preventing, evaluating and treating IFIs in this patient group.

Suggested Citation

  • Funda TekkeÅŸin1 & Zühre Kaya & Ãœlker Koçak & Ä°dil Yenicesu & EmineBetül Derinkuyu & Alp Özgün Börcek & BurcuCeylanCura Yayla & Hasan Tezer & AyÅŸe Kalkanci & Alper Ceylan, 2018. "Successful Treatment of Disseminated Fungal Infections in three Pediatric Patients with Acute Lymphoblastic Leukemia," Open Access Blood Research & Transfusion Journal, Juniper Publishers Inc., vol. 2(1), pages 1-4, February.
    • Handle: RePEc:adp:joabtj:v:2:y:2018:i:1:p:1-4
    DOI: 10.19080/OABTJ.2018.02.555576
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    Keywords

    Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access ; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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