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Implications of HLA in Transfusion Related Immune Complications Like TRALI and Platelet Refractoriness

Author

Listed:
  • Meenakshi Singh
  • Selma D’Silva
  • Anisha Navkudkar

    (HLA and Immunogenetics Laboratory, Department of Transfusion Medicine, Tata Memorial Hospital, India)

Abstract

Transfusion-related acute lung injury (TRALI) is defined as a new acute lung injury (ALI) that develops during or within 6 hours of transfusion and is a leading cause of transfusion-related morbidity and mortality [1]. The causative antibodies in TRALI may be directed against class I or II human leukocyte antigens (HLA) or human neutrophil antigens (HNA). It may also be caused by lipid products from the cellular breakdown, which accumulates in stored blood products and prime, activate neutrophils. TRALI can occur in patients undergoing repeated platelet transfusions and has mortality rates between 6-20%. Thus, it is important to identify these cases and address the issues related to the patients and implicated donors. such as bleeding or thrombosis.

Suggested Citation

  • Meenakshi Singh & Selma D’Silva & Anisha Navkudkar, 2018. "Implications of HLA in Transfusion Related Immune Complications Like TRALI and Platelet Refractoriness," Open Access Blood Research & Transfusion Journal, Juniper Publishers Inc., vol. 1(5), pages 103-105, February.
    • Handle: RePEc:adp:joabtj:v:1:y:2018:i:5:p:103-105
    DOI: 10.19080/OABTJ.2018.01.555574
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    Keywords

    Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access ; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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