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Correlation of Acute Chest Syndrome with e-NOS, ARG1 and GSNOR Gene Polymorphisms in Omani Sickle Cell Patients

Author

Listed:
  • Aiman Al Wahaibi

    (Department of Medicine, Oman Medical Specialty Board, Oman)

  • Anil Pathare

    (Department of Haematology, Sultan Qaboos University Hospital, Oman)

  • Shoaib Al Zadjali

    (College of Medicine and Health Sciences, Oman)

  • Salam Alkindi

    (Department of Haematology, Sultan Qaboos University Hospital, Oman
    College of Medicine and Health Sciences, Oman)

Abstract

Acute chest syndrome (ACS), is the most common pulmonary complication of sickle cell disease (SCD) and reduced nitric oxide (NO) is considered to play a significant role. NO induces vasodilatation and helps in the recruitment of neutrophils. However, the endothelial nitric oxide synthase (NOS3) gene polymorphisms T-786C significantly reduces eNOS gene promoter activity, whereas the E298D changes an amino acid in the enzyme’s oxygenase domain. The expression of eNOS is also related to the number of 27bp repeat VNTRs in intron 4, with genotype 4bb showing a decrease in eNOS expression whereas, homozygosity for the minor allele of GSNOR SNP rs28730619 is associated with increased risk of asthma. such as bleeding or thrombosis.

Suggested Citation

  • Aiman Al Wahaibi & Anil Pathare & Shoaib Al Zadjali & Salam Alkindi, 2018. "Correlation of Acute Chest Syndrome with e-NOS, ARG1 and GSNOR Gene Polymorphisms in Omani Sickle Cell Patients," Open Access Blood Research & Transfusion Journal, Juniper Publishers Inc., vol. 1(5), pages 100-102, January.
    • Handle: RePEc:adp:joabtj:v:1:y:2018:i:5:p:100-102
    DOI: 10.19080/OABTJ.2018.01.555573
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    Keywords

    Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access ; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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