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Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients

Author

Listed:
  • Christin Weise

    (Department of Dermatology and Allergology, Allergy-Center-Charité, Charité-Universitätsmedizin, Germany)

  • Margitta Worm

    (NBS Scientific GmbH, Weinheim, Germany)

  • Ralph Rühl

    (Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary
    Paprika Bioanalytics BT, Debrecen, Hungary)

Abstract

Vitamin D-mediated signalling is discussed controversial in regard of allergic sensitization and atopic dermatitis (AD). In this study we determined that in AD patients two main target genes of vitamin D-mediated signalling CYP24A1 (vitamin D 24-hydroxylase) and TSLP (thymic stromal lymphopoietin) are strongly upregulated in both affected as well as non-affected skin of AD patients vs healthy volunteers skin. We conclude that this increased local vitamin D-mediated signalling resulting is in a strong local pro-inflammatory and pro-allergic conditions present in the skin of AD patients with an impact on the systemic vitamin D-signalling and systemic allergic sensitization.

Suggested Citation

  • Christin Weise & Margitta Worm & Ralph Rühl, 2020. "Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients," JOJ Dermatology & Cosmetics, Juniper Publishers Inc., vol. 3(4), pages 76-78, December.
    • Handle: RePEc:adp:jjojdc:v:3:y:2020:i:4:p:76-78
    DOI: 10.19080/JOJDC.2020.03.555618
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