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Effects of Ethanol Extract Leaves of nymphaea lotus (water lily) on Learning and Memory in CD-1 Mice

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  • Nomso C
  • Aduema W

    (Department of Human Physiology, Gregory University, Nigeria)

Abstract

Nymphea lotusis a perennial and herbaceous aquatic plant, whose leaves floats or submerged in water across the regions of Africa. The plant has be reportedly used for various therapeutic purposes (such as aphrodisiac, antioxidant and antibacterial purposes) including the treatment of fever, diarrhea, urinary difficulties, enteritis, dyspepsia, bowel problems tumours, gastric ulcers and abnormal heart beat. The present study investigates the effect of the ethanolic extract of Nympheae lotus on learning and memory in mice. The Morris water maze test was used to evaluate the neuro-cognitive effects of this plant. Before the neurobehavioral parameters were assessed, the LD50, Photochemical and acute toxicological screenings of the plant were determined. The median lethal dose was above 5000mg/kg orally in mice for the ethanol extract. Twenty seven (27) Swiss mice were randomly assigned into 3 groups; control (normal saline), low dose (200mg/kg) and high dose (400mg/kg) for fourteen days (14).

Suggested Citation

  • Nomso C & Aduema W, 2018. "Effects of Ethanol Extract Leaves of nymphaea lotus (water lily) on Learning and Memory in CD-1 Mice," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 4(3), pages 55-62, January.
    • Handle: RePEc:adp:jgjpps:v:4:y:2018:i:3:p:55-62
    DOI: 10.19080/GJPPS.2018.04.555638
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    References listed on IDEAS

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    1. Aduema W, 2016. "Neurobehioural Effects of Chronic Consumption of Uncooked Black Eye Beans on Spatial Learning and Memory in Mice," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 1(2), pages 27-31, December.
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