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Spermidine for a Long, Dementia-Free Life?

Author

Listed:
  • Tsikas D
  • Erik Hanff
  • Gorig Brunner

    (Core Unit Proteomics, Hannover Medical School, Germany)

Abstract

Spermidine, N-(3-aminopropyl) butane-1,4-diamine, is an endogenous basic compound known for more than 90 years. The biosynthesis of spermidine, its pharmacological properties including distribution, metabolism and excretion have been thoroughly investigated. Spermidine and other polyamines have been early associated with growth and aging, and were found to stabilize various cellular and subcellular components including nucleic acids due to their polyvalent cationic structures. Polyamines including spermidine have been found at elevated circulating and urinary concentrations in a variety of diseases including cancer and psoriasis. Thus, decreasing the concentration of polyamines mainly by inhibiting their biosynthesis is regarded as a realistic therapeutical strategy. Yet, more recent studies suggest that exogenous spermidine exerts beneficial effects on the brain where it protects from age-induced memory impairment, protects the heart and extents lifespan.

Suggested Citation

  • Tsikas D & Erik Hanff & Gorig Brunner, 2017. "Spermidine for a Long, Dementia-Free Life?," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 2(1), pages 1-8, April.
    • Handle: RePEc:adp:jgjpps:v:2:y:2017:i:1:p:1-8
    DOI: 10.19080/GJPPS.2017.02.555576
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