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Etilefrine Could Improve Response to Standard Medical Therapy in Chronic Hepatitis C Egyptian Patients with Cirrhotic Refractory Ascites: A Randomized Pilot Study

Author

Listed:
  • Ahmed MA

    (Department of Clinical Pharmacy, Faculty of Pharmacy, Egypt)

  • Awaad TG

    (General Authority of Health Insurance, Egypt)

Abstract

Ascites is a frequent complication of cirrhosis that accounts for over 75% of episodes of ascites. Patients with cirrhotic ascites have marked splanchnic vasodilation and arterial hypotension with subsequent activation of vasoconstrictive and anti-natriuretic mechanisms. One of the most serious complications in cirrhotic patients with ascites is the occurrence of refractoriness that is the inability to resolve ascites by the standard medical treatment. The aim of this study is to evaluate the effects of etilefrine on systemic hemodynamics, renal function and control of ascites in chronic hepatitis C (CHC) patients with cirrhotic refractory ascites receiving standard medical treatment (SMT) with low sodium diet and maximal diuretic doses of 160mg/day of furosemide and 400mg/day of spironolactone.

Suggested Citation

  • Ahmed MA & Awaad TG, 2017. "Etilefrine Could Improve Response to Standard Medical Therapy in Chronic Hepatitis C Egyptian Patients with Cirrhotic Refractory Ascites: A Randomized Pilot Study," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 1(5), pages 119-126, April.
    • Handle: RePEc:adp:jgjpps:v:1:y:2017:i:5:p:119-126
    DOI: 10.19080/GJPPS.2017.01.555572
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