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The Recombinant Vaccine against Human Chorionic Gonadotropin goes on Combined Immunogenicity, Safety and Efficacy Clinical Trials

Author

Listed:
  • Talwar GP
  • Jagdish C Gupta
  • Kripa N Nand

    (Talwar Research Foundation, India)

  • Radhey S Sarma

    (Indian Council of Medical Research, India)

  • Bandivdekar AH

    (National Institute for Research in Reproductive Health, India)

  • Rohini Sehgal
  • Indrani Ganguli
  • Alka Kriplani

    (All India Institute of Medical Sciences, India)

Abstract

A chemically synthesized vaccine inducing antibodies against human chorionic gonadotropin (hCG) was previously developed by Talwar et al. [1] which had undergone successfully Phase I and Phase II efficacy Clinical trials in sexually active women showing its ability to prevent pregnancy without derangement of ovulation,hormonal profiles and menstrual regularity (Table 1). It had high efficacy with only one pregnancy occurring in 1224 cycles. It was fully reversible and women desirous of having another child conceived readily on antibodies falling below 20ng/ml binding capacity [2]. The progeny born to previously immunized women had developmental land marks and cognitive abilities similar to their siblings [3].

Suggested Citation

  • Talwar GP & Jagdish C Gupta & Kripa N Nand & Radhey S Sarma & Bandivdekar AH & Rohini Sehgal & Indrani Ganguli & Alka Kriplani, 2018. "The Recombinant Vaccine against Human Chorionic Gonadotropin goes on Combined Immunogenicity, Safety and Efficacy Clinical Trials," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 5(1), pages 12-15, July.
    • Handle: RePEc:adp:jgjorm:v:5:y:2018:i:1:p:12-15
    DOI: 10.19080/GJORM.2018.05.555654
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