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Corneal Defects and Stem Cell Therapeutics

Author

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  • Ravi Kant Upadhyay

    (Department of Zoology, DDU Gorakhpur University, India)

Abstract

This article explains important corneal defects/disorders; and therapeutic applications of stem cells for restoration of vital functions. This article also describes use stem cells and their transplantation for retrieving of corneal functions. This article also tries to explain cell culture methods for corneal organoid culture that include multiple corneal cell types and extracellular matrices. It also describes removal of corneal blindness by grafting with cadaveric tissues, maintenance of corneal transparency and restoration of corneal endothelial dysfunction and visual impairment. Present review presents new advancements made in the field of biocompatible substrates, bio-matrix, transplantation methods and micro-niche maintaining factors for restoration, repairing and healing of corneal epithelial cell successfully. This article suggests dire need to explore and design new biomaterials to make matrix based nano-structure constructs for corneal repair and regeneration.

Suggested Citation

  • Ravi Kant Upadhyay, 2017. "Corneal Defects and Stem Cell Therapeutics," Global Journal of Intellectual & Developmental Disabilities, Juniper Publishers Inc., vol. 3(1), pages 9-28, September.
    • Handle: RePEc:adp:jgjidd:v:3:y:2017:i:1:p:9-28
    DOI: 10.19080/GJIDD.2017.03.555603
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