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Management of Small Cell Neuroendocrine Carcinoma of Urinary Bladder, A Case Series from Northern Pakistan

Author

Listed:
  • Humera Mahmood

    (Head of department Oncology, Atomic Energy Cancer Hospital, Pakistan)

  • Hadia Fatima

    (Resident Oncology, Atomic Energy Cancer Hospital, Pakistan)

  • Mohammad Faheem

    (Chief Oncologist and Director, Atomic Energy Cancer Hospital, Pakistan)

Abstract

Small cell neuroendocrine carcinoma is a rare histological variant of urinary bladder malignancies. The clinical behavior is aggressive and prognostic outcome is very poor in such cases. Patient’s presentation may correspond to bladder tumors but may exhibit characteristic features of neuroendocrine malignancies. The tumor is diagnosed histologically and through immunohistochemical stains. This tumor is usually picked up in advanced stages. Cisplatin and etoposide is the first line chemotherapy usually administered in these cases. Patients not responding to chemotherapy might benefit from palliative radiotherapy. Three of these cases have been reported in this case series emphasizing the role of correct diagnosis of Small cell bladder tumors. All of these patients were diagnosed initially as urothelial tumors. They were picked up later in advanced stages. Patients were managed at the oncology department initially with combination chemotherapy but most of them had a relapse and had to be planned for locoregional palliative radiotherapy

Suggested Citation

  • Humera Mahmood & Hadia Fatima & Mohammad Faheem, 2018. "Management of Small Cell Neuroendocrine Carcinoma of Urinary Bladder, A Case Series from Northern Pakistan," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 9(1), pages 13-16, January.
    • Handle: RePEc:adp:jctoij:v:9:y:2018:i:1:p:13-16
    DOI: 10.19080/CTOIJ.2018.09.555754
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