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Formulas of Integration of Permissivity and of Directed Molecular Targeting In Oncogenesis

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  • Lawrence M Agius

    (Department of pathology, University Of Malta Medical School, Malta,)

Abstract

Dimensions of non-resolution or paradoxically of resolved integrative action allow for a dualized context of constitutive receptor activity and of permissiveness in the creation of the malignant phenotype of cancer cells. The proposition for such permissiveness is compounded by resolved end-result in oncogenesis that is projected in terms of aberrant over-activity of tyrosine kinases that include dimensions of over-activity in the face of non-resolved dynamics of spread and metastasis. It is within such dimensional context that the oncogenesis is portrayed as established pathways within a permissive context for further change progression. Growth factors and transcription factors allow for such permissiveness to integrate with the directed targeting of molecules in terms of protein-protein interactivity and tyrosine kinase formulations.

Suggested Citation

  • Lawrence M Agius, 2018. "Formulas of Integration of Permissivity and of Directed Molecular Targeting In Oncogenesis," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 8(5), pages 90-93, January.
    • Handle: RePEc:adp:jctoij:v:8:y:2018:i:5:p:90-93
    DOI: 10.19080/CTOIJ.2018.08.555749
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