IDEAS home Printed from https://ideas.repec.org/a/adp/jctoij/v10y2018i4p60-62.html
   My bibliography  Save this article

Hyper-Proliferation of Cell Action versus Apoptosis/Non-Apoptosis in Myc Amplification in Inducing Oncogenesis

Author

Listed:
  • Lawrence M Agius

    (Department of Pathology, University of Malta Medical School, Europe)

Abstract

The prevention of otherwise enhanced pro-apoptosis is signal targeting for the amplified MYC that induces powerful proliferation-prone dysjunction between contrasting apoptosis and non-apoptosis as evident especially in the context of metabolic over activity and switching to aerobic glycolysis of the Warburg phenomenon. It is the copy-number variability of amplified MYC that induces modulated non-apoptosis that paradoxically is enhanced within contexts of increased protein synthesis and of hyper-proliferation of cells. Additionally, there evolves the constitutive dimensions for transformation that opts for non-apoptosis of highly proliferative cells and of stem cells that are prevented to undergo terminal differentiation.

Suggested Citation

  • Lawrence M Agius, 2018. "Hyper-Proliferation of Cell Action versus Apoptosis/Non-Apoptosis in Myc Amplification in Inducing Oncogenesis," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 10(4), pages 60-62, May.
    • Handle: RePEc:adp:jctoij:v:10:y:2018:i:4:p:60-62
    DOI: 10.19080/CTOIJ.2018.10.555793
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/ctoij/pdf/CTOIJ.MS.ID.555793.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/ctoij/CTOIJ.MS.ID.555793.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/CTOIJ.2018.10.555793?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:jctoij:v:10:y:2018:i:4:p:60-62. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.