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Decellularized Human Liver Tissue Fragments to Create Cell - and Tissue-Engineered Liver Constructs

Author

Listed:
  • Nemets EA
  • Kirsanova LA
  • Basok Ju B
  • Lymareva MV
  • Schagidulin M Ju
  • Sevastianov

    (Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation, Russia)

Abstract

One of the problems of creating a bioengineered liver as an alternative to the donor liver transplantation for the treatment of end-stage liver failure, is finding the matrix, capable of performing temporarily the functions of a natural extracellular matrix (ECM) and providing the necessary conditions to maintain the viability and functionality of liver cells. The main disadvantage of resorbable biopolymer matrices is the absence of tissue-specific properties and the impossibility of reproducing the unique structure of the liver ECM. The aim of this work was the development of technology for decellularization of liver tissue fragments while preserving the structural properties of the native liver ECM.

Suggested Citation

  • Nemets EA & Kirsanova LA & Basok Ju B & Lymareva MV & Schagidulin M Ju & Sevastianov, 2017. "Decellularized Human Liver Tissue Fragments to Create Cell - and Tissue-Engineered Liver Constructs," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 8(5), pages 112-115, August.
    • Handle: RePEc:adp:jctbeb:v:8:y:2017:i:5:p:112-115
    DOI: 10.19080/CTBEB.2017.08.555747
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