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CRISPR/Cas Systems in Tissue Engineering: A Succinct Overview of Current Use and Future Opportunities

Author

Listed:
  • Diego A Velasquez Pulgarin
  • Gary L Bowlin

    (Department of Biomedical Engineering, University of Memphis, USA)

  • William A Nyberg
  • Alexander Espinosa

    (Department of Biomedical Engineering, University of Memphis, USA)

Abstract

Tissue engineering is a broad field that aims to restore or maintain the function of tissues and organs. Despite progress in the field, non-trivial obstacles have prevented the widespread adoption of tissue engineered products. Genome editing and synthetic biology approaches may be suitable strategies to tackle a number of these obstacles. Clustered regularly interspaced short palindromic repeats systems have revolutionized genome engineering and facilitated its adoption by many non-specialized laboratories, allowing tissue engineering laboratories to genetically modify cells for applications ranging from immune response circumvention to in vitro 3D micro tissue model development. This review presents a brief overview of the current use and future applications of clustered regularly interspaced short palindromic repeats systems in tissue engineering.

Suggested Citation

  • Diego A Velasquez Pulgarin & Gary L Bowlin & William A Nyberg & Alexander Espinosa, 2017. "CRISPR/Cas Systems in Tissue Engineering: A Succinct Overview of Current Use and Future Opportunities," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 5(4), pages 93-96, July.
    • Handle: RePEc:adp:jctbeb:v:5:y:2017:i:4:p:93-96
    DOI: 10.19080/CTBEB.2017.05.555670
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