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Prospects to Enhance Phage Therapy by Looking At CRISP Fingerprints in Bacterial Populations

Author

Listed:
  • Vladimir Zlobin I
  • Yuri Dzhioev P
  • Nadezhda Peretolchina P
  • Andrey Borisenko Y
  • Liliya Stepanenko A

    (Scientific and Research Institute of Biomedical Technologies of the Irkutsk State Medical University, Russia)

  • Yingchen Wang
  • Zhangyi Qu
  • Rian Pierneef

    (Department Microbiology, Harbin Medical University, 157, China)

  • Oleg Reva N
  • Rian Pierneef

    (Department of Biochemistry, University of Pretoria, South Africa)

Abstract

In the last decade CRISPR/Cas systems have been used extensively in different areas of research from bacterial genotyping to genetic engineering. CRISPR/Cas systems are accurate and precise molecular devices designed by the nature, with the primary role being bacterial defence against foreign genetic elements, mainly bacteriophages. The recent advances in sequencing technologies have created opportunities for application of CRISPR/Cas systems in personalized phage therapy and in fundamental studies of co-functioning of bacterial and phage populations in the nature. However, as always, new opportunities mean new technical challenges and demands for innovative bioinformatics tools. This review introduces an initiative of the BRICS consortium, consisting of three research centres in Russia, China and South Africa, to develop a comprehensive interactive resource to source data and software tools for personalised phage therapy.

Suggested Citation

  • Vladimir Zlobin I & Yuri Dzhioev P & Nadezhda Peretolchina P & Andrey Borisenko Y & Liliya Stepanenko A & Yingchen Wang & Zhangyi Qu & Rian Pierneef & Oleg Reva N & Rian Pierneef, 2018. "Prospects to Enhance Phage Therapy by Looking At CRISP Fingerprints in Bacterial Populations," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 10(5), pages 99-101, January.
    • Handle: RePEc:adp:jctbeb:v:10:y:2018:i:5:p:99-101
    DOI: 10.19080/CTBEB.2018.10.555800
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