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Applications of Antisense Peptide Nucleic Acid in Biomedicine and Biosciences

Author

Listed:
  • Anjali Gupta
  • Kavita Khatana

    (Department of Chemistry, Galgotias University, India)

Abstract

Peptide Nucleic Acids (PNAs) are synthetic mimics of DNA/ RNA [1] containing N-2-aminoethylglycine repeating units in place of sugar-phosphate backbone of DNA or RNA. Due to the absence of electrostatic repulsions, PNA/DNA duplexes are thermally more stable as compared to DNA/DNA double helix. The sequence selective nature and mismatch intolerance of PNA probes make them useful in biomedical and biosciences applications [2]. PNAs can be used as antisense agents that block the translation process and inhibit the synthesis of targeted protein. These antisense oligonucleotides are used to treat genetic mutations or different infections.

Suggested Citation

  • Anjali Gupta & Kavita Khatana, 2017. "Applications of Antisense Peptide Nucleic Acid in Biomedicine and Biosciences," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 10(3), pages 56-57, December.
    • Handle: RePEc:adp:jctbeb:v:10:y:2017:i:3:p:56-57
    DOI: 10.19080/CTBEB.2017.10.555789
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