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Microneedles: A Potent Modern Tool in Enhancing Transdermal Drug Delivery

Author

Listed:
  • Ogundele MI

    (Department of Biomedical Engineering, Binghamton University, USA)

  • Okafor HK

    (Department of Biochemistry, College of Medicine, University of Lagos, Nigeria)

Abstract

The conventional drug delivery methods commonly used are oral administration and injection. However there a limitation posed against the penetration of these substances in therapeutic amounts via the corneum stratum. There has been an increasing emphasis on Transdermal drug delivery which provides a better prospect than the two conventional methods. Transdermal drug delivery provides quite a number of merits which include sustained release, prevention of gastric irritation, improvement in patience compliance as well as removal of pre-systemic first-pass effect. In recent times, microneedles are being proposed for use in enhancing Transdermal drug delivery as the use of microneedles increases skin permeability. This review is a qualitative attempt as discussing the microneedle as a potent modern tool in enhancing transdermal drug delivery. This starts with the explanation of the skin and microneedles. Then the mechanism of action of microneedles, the advantages and disadvantages of microneedles are also discussed. The review ends with the recent advances in the application of microneedles in transdermal drug delivery.

Suggested Citation

  • Ogundele MI & Okafor HK, 2017. "Microneedles: A Potent Modern Tool in Enhancing Transdermal Drug Delivery," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 10(1), pages 1-9, October.
    • Handle: RePEc:adp:jctbeb:v:10:y:2017:i:1:p:1-9
    DOI: 10.19080/CTBEB.2017.10.555776
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