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Advances in Neutrophil Testing In Type 2 Diabetes Mellitus

Author

Listed:
  • Han Wei Hou

    (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore)

  • Hui Min Tay

    (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore)

  • Rinkoo Dalan

    (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
    Endocrine and Diabetes, Tan Tock Seng Hospital, Singapore)

  • Bernhard O Boehm

    (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
    Endocrine and Diabetes, Tan Tock Seng Hospital, Singapore
    Imperial College London, UK)

Abstract

Patients with type 2 diabetes mellitus (T2DM) suffer from impaired glucose metabolism which results in low-grade inflammation and activation of the innate immune system. Neutrophils the key effector cells of the innate immune system and heavily implicated in the pathogenesis of T2DM, are promising cell-based inflammatory biomarkers for immune health profiling, provided that they can be rapidly purified and measured with sufficient precision. In this review, we highlight recent advances in neutrophil isolation and functional assay using microfluidics technologies and the potential of their functional phenotype as a novel biomarker of vascular risk in diabetes.

Suggested Citation

  • Han Wei Hou & Hui Min Tay & Rinkoo Dalan & Bernhard O Boehm, 2017. "Advances in Neutrophil Testing In Type 2 Diabetes Mellitus," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 1(5), pages 92-962:1, March.
    • Handle: RePEc:adp:jcrdoj:v:1:y:2017:i:5:p:92-96
    DOI: 10.19080/CRDOJ.2017.01.55552
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    More about this item

    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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