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GPR119 and GPR131: Functional Difference?

Author

Listed:
  • Yingxiao Li

    (Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    Department of Medical Research, Chi-Mei Medical Center, Taiwan)

  • Kai Chun Cheng

    (Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan)

  • Juei-Tang Cheng

    (Department of Medical Research, Chi-Mei Medical Center, Taiwan
    Institute of Medical Science, Chang Jung Christian University, Taiwan)

Abstract

Recently, two strategies are generally applied in clinical practice to treat diabetes, namely, glucagon like peptide-1 (GLP-1) analogs and inhibitors of the enzyme dipeptidylpeptidase-IV (DPP-4) that degrades both GLP-1 and glucose dependent insulin tropic polypeptide (GIP). Physiologically, after food ingestion, enteroendocrine cells in the intestinal mucosa may release the incretins, including GLP-1 and GIP, that can stimulate insulin secretion from endocrine pancreas and thereby decrease blood glucose. GLP-1 is produced and released mainly by L-cells located in the distal ileum while GIP is secreted by enteroendocrine K-cells in the proximal gut. However, GIP is not focused in clinics because diabetic patients are mostly GIP resistant. Therefore, development of agent(s) that may enhance GLP-1 pathway received increasing attentions in recent.

Suggested Citation

  • Yingxiao Li & Kai Chun Cheng & Juei-Tang Cheng, 2017. "GPR119 and GPR131: Functional Difference?," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 1(3), pages 71-732:1, March.
    • Handle: RePEc:adp:jcrdoj:v:1:y:2017:i:3:p:71-73
    DOI: 10.19080/CRDOJ.2017.01.555566
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    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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