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Bayesian Genotoxicity

Author

Listed:
  • Keon Woo Kim

    (Department of Statistics, Pennsylvania State University, USA)

  • JB Kadane

    (Department of Statistics, Carnegie Mellon University, USA)

Abstract

This paper reports an initial exploration relating the genotoxicity of chemicals tested in vivo to the genotoxicity of chemical structures (sets of chemicals with common components). The analysis uses genotoxic results on 568 chemicals to make inference about the genotoxicity of 2893 chemical structures. As a result, there is substantial residual uncertainty. Two simple models are proposed to relate the genotoxicity of a chemical to the genotoxicity of its component chemical structures.

Suggested Citation

  • Keon Woo Kim & JB Kadane, 2018. "Bayesian Genotoxicity," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 5(2), pages 54-58, February.
    • Handle: RePEc:adp:jbboaj:v:5:y:2018:i:2:p:54-58
    DOI: 10.19080/BBOAJ.2018.05.555660
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