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High Risk HPV, HSIL and Primary Diffuse Large B Cell Lymphoma of Cervix: An Unsual Case

Author

Listed:
  • Sreekala Sreehari

    (Department of Histopathology, NMC Royal Hospital, UAE)

  • Mohanad Diab

    (Department of Medical oncology, NMC Royal Hospital, UAE)

  • Paulina Manosalvas Martinez

    (Department of Obstetrics and Gynecology, NMC Royal Hospital, UAE)

Abstract

Primary malignant non-Hodgkin’s lymphomas in the female genital tract are rare, accounting for less than 1% of all extranodal non-Hodgkin’s lymphomas. HPV infection has well been documented as the causative factor for Carcinoma cervix; not malignant lymphoma of cervix. Here we report an interesting case of primary non-Hodgkin’s lymphomas of uterine cervix with proven HPV 16 infection and High grade squamous intraepithelial lesion with co-existing diffuse large B-cell lymphomas (DLBCL) on histopathological examination and immunohistochemical study. The patient was successfully treated with chemotherapy after Cervical Conisation for HSIL and is now in complete remission with follow up period of 11 months. Gynecological lymphomas can be a diagnostic challenge due to nonspecific symptoms. However, when diagnosed and treated they have a good prognosis. Clinicians should therefore include lymphoma in their differential diagnosis when investigating gynecological symptoms.

Suggested Citation

  • Sreekala Sreehari & Mohanad Diab & Paulina Manosalvas Martinez, 2019. "High Risk HPV, HSIL and Primary Diffuse Large B Cell Lymphoma of Cervix: An Unsual Case," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(4), pages 71-73, January.
    • Handle: RePEc:adp:ijcsmb:v:5:y:2019:i:4:p:71-73
    DOI: 10.19080/IJCSMB.2019.04.555666
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