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Refining the Role of Autophagy in Hypertrophic Cardiomyopathy

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Listed:
  • Shuyi Wang
  • Jun Ren

    (University of Wyoming College of Health Sciences, USA)

Abstract

Hypertrophic cardiomyopathy is perhaps the most prevalent form of inherited cardiomyopathy as a result of mutations in genes encoding components of the cardiac sarcomere. Although diagnosis of hypertrophic cardiomyopathy is relatively straightforward, its clinical management has been challenging due to lack of knowledge with regards to the precise pathogenesis of hypertrophic cardiomyopathy. A large body of evidence has recently suggested a pivotal role for impaired protein quality control machinery in inherited cardiomyopathies including hypertrophic cardiomyopathy. Here we will review recent findings on the role of autophagy in the etiology of hypertrophic cardiomyopathy and discuss therapeutic options available to restore autophagy-lysosomal function in an effort to benefit cardiac homeostasis in hypertrophic cardiomyopathy.

Suggested Citation

  • Shuyi Wang & Jun Ren, 2018. "Refining the Role of Autophagy in Hypertrophic Cardiomyopathy," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 4(3), pages 48-50, April.
    • Handle: RePEc:adp:ijcsmb:v:4:y:2018:i:3:p:48-50
    DOI: 10.19080/IJCSMB.2018.03.555637
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    References listed on IDEAS

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    1. Ichizo Nishino & Jin Fu & Kurenai Tanji & Takeshi Yamada & Sadatomo Shimojo & Tateo Koori & Marina Mora & Jack E. Riggs & Shin J. Oh & Yasutoshi Koga & Carolyn M. Sue & Ayaka Yamamoto & Nobuyuki Murak, 2000. "Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)," Nature, Nature, vol. 406(6798), pages 906-910, August.
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