IDEAS home Printed from https://ideas.repec.org/a/adp/ijcsmb/v3y2017i4p59-62.html
   My bibliography  Save this article

Role of Structural Dynamics in Leukocyte Integrins Function Interplay between the Shape-Shifting Mechanism and Allostery

Author

Listed:
  • Pragya Manandhar
  • Omar Abousaway
  • Trevor Le
  • Mehmet Sen

    (Department of Biology and Biochemistry, University of Houston, USA)

Abstract

This review concerns the recent progress on structural characterization of leukocyte integrins. Leukocyte integrins, also called CD18-integrins, are exclusively expressed on the leukocyte cell surface and modulate their trafficking in vasculature. Therefore, these integrins are major drug targets in autoimmune pathologies. Through initial drug development efforts, Efalizumab (Raptiva), designed to antagonize ligand-affinity of the LFA-1 integrin, was initially approved and originally marketed to treat psoriasis. However, the FDA and European Medicines Agency recommended suspension of Raptiva due to risk of progressive multifocal leukoencephalopathy (PML) as a result of immune suppression and concomitant activation of John Cunningham virus. In short, there is still an urgent need to design 2nd generation of anti-inflammatory drugs. Therefore, recent structural studies on leukocyte integrins, which have depicted unprecedented local and global motions, could be beneficial in the structure-guided drug design strategies.

Suggested Citation

  • Pragya Manandhar & Omar Abousaway & Trevor Le & Mehmet Sen, 2017. "Role of Structural Dynamics in Leukocyte Integrins Function Interplay between the Shape-Shifting Mechanism and Allostery," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 3(4), pages 59-62, October.
    • Handle: RePEc:adp:ijcsmb:v:3:y:2017:i:4:p:59-62
    DOI: 10.19080/IJCSMB.2017.03.555617
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/ijcsmb/pdf/IJCSMB.MS.ID.555617.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555617.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/IJCSMB.2017.03.555617?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:ijcsmb:v:3:y:2017:i:4:p:59-62. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.