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Prognostic and Clinicopathological Value of SIRT1 Expression in Female Reproductive System Cancer

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Listed:
  • Shuai Zhang
  • Zhe Sun
  • Yuewen Qi
  • Xiaolu Fang
  • Hong Yu

Abstract

Objective: Numerous epidemiological studies have reported the association between silent mating type information regulation 2 homolog-1 (SIRT1) and female reproductive system cancer, but the data of different reports remains controversial. To accurately evaluate the significance of SIRT1 expression in reproductive system cancer, a meta-analysis based on published studies was conducted. Methods: Relevant articles before August 2017 on SIRT1 and reproductive system cancer were searched via PubMed, Embase, Cochrane Central and Chinese National Knowledge Infrastructure databases(NCBI). The studies were chosen for the meta-analysis based on requisite criteria. The overall survival (OS) and clinical features including FIGO stage , lymph node metastasis (LNM) and tumor grade were analyzed using RevMan 5.3 software. Odds ratios (OR) , hazard ratios (HR) and their 95% corresponding confidence intervals (CI) were pooled to estimate the effect of specific associations. Results: A total of 14 eligible studies containing 1002 patients were enrolled, in which 47.9% of the patients overexpressed SIRT1. The results showed that SIRT1 overexpression significantly correlated with the risk of reproductive cancers (OR=3.92, 95% CI: 3.06–5.02, P

Suggested Citation

  • Shuai Zhang & Zhe Sun & Yuewen Qi & Xiaolu Fang & Hong Yu, 2018. "Prognostic and Clinicopathological Value of SIRT1 Expression in Female Reproductive System Cancer," International Journal of Sciences, Office ijSciences, vol. 7(01), pages 57-65, January.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:1:p:57-65
    DOI: 10.18483/ijSci.1510
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    References listed on IDEAS

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    1. Shin-ichiro Imai & Christopher M. Armstrong & Matt Kaeberlein & Leonard Guarente, 2000. "Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase," Nature, Nature, vol. 403(6771), pages 795-800, February.
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