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The Expression and Prognosis of Caspase-9 in Hepatocellular Carcinoma

Author

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  • Xiaohui SUN
  • Lingling SUN
  • Chen Jiang
  • Zhiqiang QIN
  • Mei Lin

Abstract

Objective: We aim to investigate the expression of Caspase-9 and its prognostic significance in hepatocellular carcinoma (HCC). Methods: The expression of Caspase-9 in 108 specimens of HBV-related HCC, 30 cases of cirrhosis tissue and 20 cases of normal liver tissue was examined by immunohistochemical staining. And we explored the relationship of Caspase-9 with clinicopathological parameters, 5-year overall survival (OS) and disease-free survival (DFS) in HCC patients. Results: Caspase-9 expression in HCC was significantly higher than that in normal liver tissue (χ2 = 4.349, P = 0.037). The expression of Caspase-9 was not different both between normal liver tissue and cirrhosis, cirrhosis and HCC (χ2 = 0.347, P = 0.556; χ2 = 2.713, P = 0.100). Caspase-9 expression in HCC was correlated with Edmondson grade and satellite nodule (P = 0.001 and P = 0.005, respectively). Survival analysis showed that Caspase-9 expression was associated with OS and DFS (P = 0.001 and P = 0.006, respectively). Conclusion: The expression of Caspase-9 correlated with the carcinogenesis and progression of HCC. Assessment the expression of Caspase-9 may predict the recurrence and survival of HCC patients.

Suggested Citation

  • Xiaohui SUN & Lingling SUN & Chen Jiang & Zhiqiang QIN & Mei Lin, 2017. "The Expression and Prognosis of Caspase-9 in Hepatocellular Carcinoma," International Journal of Sciences, Office ijSciences, vol. 6(04), pages 88-95, April.
    • Handle: RePEc:adm:journl:v:6:y:2017:i:4:p:88-95
    DOI: 10.18483/ijSci.1254
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