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A New Inhibitor of γ-aminobutric Acid Aminotransferase from Streptomyces sp. ZZ035 Isolated from a Folk Medicinal Soil in China

Author

Listed:
  • Xuejie Xu
  • Xuejiao Wu
  • Ganjun Yuan
  • Qiwang Zhong
  • Li Xu

Abstract

Strain ZZ035 was isolated from a folk medicinal soil in China. Polyphasic taxonomy procedure indicated that this strain belonged to the genus Streptomyces and was closest to S. cinnamonensis with high similarities (99.2%) of 16S rDNA sequence. 1 was isolated from the broth of this strain and identified as 5-amonimethyl-2-iminoimidazolidine-4-carboxylic acid. Its chemical structure was established by its spectroscopic data, and 1H and 13C signals were assigned by its 1H, 13C, Dept and HSQC spectra. Considering that 1 was a γ-aminobutric acid (GABA) derivative, its inhibitory activity against GABA-aminotransferase (GABA-AT) was assayed, and the result showed that 1 can inhibit GABA-AT activity with the 50% inhibitory concentration of approximately 60 μM. As 1 was a 2,3-disubstituted GABA derivative not published before, the approximate GABA-AT inhibitory activity of 1 compared to positive control vigabatrin showed that 1 were worthy of further research and developing.

Suggested Citation

  • Xuejie Xu & Xuejiao Wu & Ganjun Yuan & Qiwang Zhong & Li Xu, 2017. "A New Inhibitor of γ-aminobutric Acid Aminotransferase from Streptomyces sp. ZZ035 Isolated from a Folk Medicinal Soil in China," International Journal of Sciences, Office ijSciences, vol. 6(03), pages 100-105, March.
    • Handle: RePEc:adm:journl:v:6:y:2017:i:3:p:100-105
    DOI: 10.18483/ijSci.1225
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