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Addition of Exogenous α-Synuclein Oligomer up-regulates Divalent Metal Transporter-1 and Ferroportin-1 in BV2 Glial Cell Lines

Author

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  • Chengkui Shi
  • Xinxing Du

Abstract

It has been confirmed that α-synuclein (α-syn) aggregation in neurons or glia and formation of Lewybodies is the remarked pathognomonic hallmark of PD. Neuropathology study have found α-Syn in abnormal aggregation often accompany with iron deposits. At present ,a lot of research confirmed that divalent metal transporter 1(DMT1), is up-regulated and ferroportin-1 is downregulated in the SN of PD and accumulate of iron in this region.Therefore understanding exogenous α-Syn oligomer whether arise this phenomenon in BV2 glial cell lines is necessary.

Suggested Citation

  • Chengkui Shi & Xinxing Du, 2016. "Addition of Exogenous α-Synuclein Oligomer up-regulates Divalent Metal Transporter-1 and Ferroportin-1 in BV2 Glial Cell Lines," International Journal of Sciences, Office ijSciences, vol. 5(11), pages 54-60, November.
    • Handle: RePEc:adm:journl:v:5:y:2016:i:11:p:54-60
    DOI: 10.18483/ijSci.1147
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