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Research on the Effect of Electroacupuncture on MDM2 Expression in a Hypoxic-Ischemic Encephalopathy Rat Model

Author

Listed:
  • Tao Xu
  • Na An
  • Wenjie Li
  • Qing Sun
  • Hui Zhang

Abstract

Aim: To explore the effect of electroacupuncture (EA) on the expression of mdm2 following hypoxic-ischemic encephalopathy (HIE). Method: The hypoxic-ischemic models were established by colligating bilateral common carotid artery in new-bore SD rats aged 7 days. All rats were randomly divided into sham-surgery, model, sham-EA, EA, antagonist and EA plus antagonist group which subdivided 1d, 3d, 7d, and 21d time-phases. Ultra-structure of neurons was observed using TEM, real-time PCR was used to determine the level of mdm2 mRNA, and the expression of mdm2 was tested with Western Blot. Results: TEM shown that At 21d, the damnification of neurons had evidently recovery with electroacupuncture treatment. The down-regulation of mdm2 was observed in electroacupuncture group, which was significantly lower than that in model groups (P

Suggested Citation

  • Tao Xu & Na An & Wenjie Li & Qing Sun & Hui Zhang, 2015. "Research on the Effect of Electroacupuncture on MDM2 Expression in a Hypoxic-Ischemic Encephalopathy Rat Model," International Journal of Sciences, Office ijSciences, vol. 4(08), pages 45-52, August.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:8:p:45-52
    DOI: 10.18483/ijSci.796
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