IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v4y2015i11p37-40.html
   My bibliography  Save this article

Extrinsic Orexin-A in Lateral Hypothalamic Area Regulates Gastric Motility in Rats

Author

Listed:
  • Luo Xu
  • Heling Hao
  • Feifei Guo
  • Xiangrong Sun
  • Yanling Gong

Abstract

The orexin neuropeptide family consists of orexin-A and orexin-B, which are coded from the same prepro-mRNA. Although peripherally administered orexin-A abolishes small intestinal interdigestive contractions in rats, it still remains unclear whether orexin-A of lateral hypothalamic area(LHA) effects on the gastric motility in rats. We selected Wistar rats as our subjects. A stainless-steel injection cannula was implanted unilaterally into the LHA. A force transducer was embedmented into the stomach to record circular muscle contractiontions in freely moving conscious rats. The gastric motility was monitored by administration of ghrelin into LHA. The changes of amplitude of constriction and frequency of gastric motility were monitored in conscious rats by a transducer. Subdiaphragmatic vagotomy was performed to elucidate the neural pathways of orexin-A. After microinjection of orexin-A into LHA 5-20 min later, Orexin-A dose-dependently increased the amplitude of contraction and accelerated frequency of gastric motility in the stomach. The effect of orexin-A on promoting the amplitude and frequency of gastric contraction disappeared after 0.5μg orexin-A +6.0μg SB-334867 mixture was microinjection into LHA. However, there was no significant changes of amplitude and frequency of gastric contraction while injection of orexin-A receptor antagonists SB-334867 alone. The stimulatory effect of orexin-A on gastric motility was abolished by subdiaphragmatic vagotomy. It is suggested that exogenous orexin-A of LHA may promote gastric motility, the effect may be accomplished through the LHA-vagus pathway.

Suggested Citation

  • Luo Xu & Heling Hao & Feifei Guo & Xiangrong Sun & Yanling Gong, 2015. "Extrinsic Orexin-A in Lateral Hypothalamic Area Regulates Gastric Motility in Rats," International Journal of Sciences, Office ijSciences, vol. 4(11), pages 37-40, November.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:11:p:37-40
    DOI: 10.18483/ijSci.858
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/858
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V4201511858.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.858?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:4:y:2015:i:11:p:37-40. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.