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PERK Signaling Pathway Involved in Lactic Acid Induced Astrocyte Damage

Author

Listed:
  • Jian-Zhong Zhang
  • Li Jing
  • Ru Yan
  • Xiang-Mei Cao
  • Qing-Ping He
  • P. Andy Li

Abstract

Diabetes is an important modifiable risk factor for cerebral ischemic stroke. It increases infraction area and restrains astrocyte activation. Meanwhile, hyperglycemia increase lactic acid and decreases pH. Lactic acid may partially be accountable for the detrimental effects of diabetes on ischemic stroke. The objective of this study was to investigate the effect of lactic acid on astrocyte viability and to explore the potential mechanisms that lactic acid enhances astrocyte cell death. Astrocytes were challenged by various concentrations of lactic acid (0, 2.5, 5，10 and 15 mM). Cell viability and PERK pathway were examined. The results showed that lactic acid resulted in astrocyte death (p

Suggested Citation

  • Jian-Zhong Zhang & Li Jing & Ru Yan & Xiang-Mei Cao & Qing-Ping He & P. Andy Li, 2014. "PERK Signaling Pathway Involved in Lactic Acid Induced Astrocyte Damage," International Journal of Sciences, Office ijSciences, vol. 3(10), pages 29-34, October.
    • Handle: RePEc:adm:journl:v:3:y:2014:i:10:p:29-34
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    Keywords

    Acidosis; Astrocyte; Lactic acid; GRP78; PERK;
    All these keywords.

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