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Investigations Of The Influence Of Sufan On Myocardial Metabolism In Cases Of Experimental Heart Failure

Author

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  • Iryna Nizhenkovskaya

    (Bogomolets National Medical University, Kiev, Ukraine)

Abstract

This article presents the results of an influence by the new non-glycoside structure, metabolic cardiotonic drug “sufan” on the energetic metabolism and oxidative homeostasis indicators—in myocardium, brain, and spleen of intact rats and rats with adriamycin-induced heart failure. It was established that sufan increased the coefficient of oxidative/reduced forms of nicotinamide coenzymes, reduced the adriamycin, causing deterioration of the energetic metabolism and the pro-oxidative-anti-oxidative homeostasis. The use of the non-glycoside structure cardiotonic drug, sufan, is recommended in order to prevent cardiotoxic effects of the anthracycline antibiotics.

Suggested Citation

  • Iryna Nizhenkovskaya, 2014. "Investigations Of The Influence Of Sufan On Myocardial Metabolism In Cases Of Experimental Heart Failure," CBU International Conference Proceedings, ISE Research Institute, vol. 2(0), pages 313-318, July.
    • Handle: RePEc:aad:iseicj:v:2:y:2014:i:0:p:313-318
    DOI: 10.12955/cbup.v2.477
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