IDEAS home Printed from https://ideas.repec.org/a/aac/ijirss/v7y2024i3p1227-1234id3221.html
   My bibliography  Save this article

Enhancing the effectiveness of paclitaxel with stigmasterol bioactive compounds for cancer treatment

Author

Listed:
  • Hanaa Ali Hussein
  • Fatin Latef Khaphi
  • Raghed Mohammed Jassem

Abstract

This study examines the anticancer activity of stigmasterol bioactive compounds combined with paclitaxel. Drug resistance and high toxicity in chemotherapy present a challenge in treating cancer. However, no study has reported the combination therapy of SS with PTX up to now. We evaluated the potential effects of stigmasterol (SS) combined with Paclitaxel (PTX) on cell viability and apoptosis in liver cancer (HepG2) and normal liver (AML 12) cells. The SS showed the highest cytotoxic effects on HepG2 cells (IC50= 117.75 µg/ml) compared to PTX (IC50= 294.59 µg/ml); however, SS and PTX did not affect normal cells, and SS caused higher apoptotic activity in the sub-G1 phase in HepG2 cells after being treated with SS alone compared to other treatments. In combination therapy for both cells, PTX: SS significantly increased cell viability (IC50 of 464.44 and 1056.44 µg/ml for HepG2 and AML 12, respectively) that differed from the drug alone and the compound, confirming that the PTX combined with SS did not enhance cytotoxic performance against HepG2 cell lines. However, this study found that PTX: SS could reduce the side effects arising from the treatment with PTX. This research indicates that SS is a potential anticancer agent for liver cancer. Furthermore, the current study introduces a novel synergistic therapy that can target various cell lines or enhance the concentration of both SS and PTX to investigate the delivery technologies of both compounds.

Suggested Citation

  • Hanaa Ali Hussein & Fatin Latef Khaphi & Raghed Mohammed Jassem, 2024. "Enhancing the effectiveness of paclitaxel with stigmasterol bioactive compounds for cancer treatment," International Journal of Innovative Research and Scientific Studies, Innovative Research Publishing, vol. 7(3), pages 1227-1234.
    • Handle: RePEc:aac:ijirss:v:7:y:2024:i:3:p:1227-1234:id:3221
    as

    Download full text from publisher

    File URL: https://ijirss.com/index.php/ijirss/article/view/3221/521
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:aac:ijirss:v:7:y:2024:i:3:p:1227-1234:id:3221. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Natalie Jean (email available below). General contact details of provider: https://ijirss.com/index.php/ijirss/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.