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GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

Author

Listed:
  • Hastie, Nicholas D.
  • van der Loos, Matthijs J. H. M.
  • Vitart, Veronique
  • Völzke, Henry
  • Wellmann, Jürgen
  • Yu, Lei
  • Zhao, Wei
  • Allik, Jüri
  • Attia, John R.
  • Bandinelli, Stefania
  • Bastardot, François
  • Beauchamp, Jonathan
  • Bennett, David A.
  • Berger, Klaus
  • Bierut, Laura J.
  • Boomsma, Dorret I.
  • Bültmann, Ute
  • Campbell, Harry
  • Chabris, Christopher
  • Cherkas, Lynn
  • Chung, Mina K.
  • Cucca, Francesco
  • de Andrade, Mariza
  • De Jager, Philip Lawrence
  • De Neve, Jan-Emmanuel
  • Deary, Ian J.
  • Dedoussis, George V.
  • Deloukas, Panos
  • Dimitriou, Maria
  • Eiríksdóttir, Guðný
  • Elderson, Martin F.
  • Eriksson, Johan G.
  • Evans, David M.
  • Faul, Jessica D.
  • Ferrucci, Luigi
  • Garcia, Melissa E.
  • Grönberg, Henrik
  • Guðnason, Vilmundur
  • Hall, Per
  • Harris, Juliette M.
  • Harris, Tamara B.
  • Heath, Andrew C.
  • Hernandez, Dena G.
  • Hoffmann, Wolfgang
  • Hofman, Adriaan
  • Holle, Rolf
  • Holliday, Elizabeth G.
  • Hottenga, Jouke-Jan
  • Iacono, William G.
  • Illig, Thomas
  • Järvelin, Marjo-Riitta
  • Kähönen, Mika
  • Kaprio, Jaakko
  • Kirkpatrick, Robert M.
  • Kowgier, Matthew
  • Latvala, Antti
  • Launer, Lenore J.
  • Lawlor, Debbie A.
  • Lehtimäki, Terho
  • Li, Jingmei
  • Lichtenstein, Paul
  • Lichtner, Peter
  • Liewald, David C.
  • Madden, Pamela A.
  • Magnusson, Patrik K. E.
  • Makinen, Tomi E.
  • Masala, Marco
  • McGue, Matt
  • Metspalu, Andres
  • Mielck, Andreas
  • Miller, Michael B.
  • Montgomery, Grant W.
  • Mukherjee, Sutapa
  • Nyholt, Dale R.
  • Oostra, Ben A.
  • Palmer, Lyle J.
  • Palotie, Aarno
  • Penninx, Brenda W. J. H.
  • Perola, Markus
  • Peyser, Patricia A.
  • Preisig, Martin
  • Räikkönen, Katri
  • Raitakari, Olli T.
  • Realo, Anu
  • Ring, Susan M.
  • Ripatti, Samuli
  • Rivadeneira, Fernando
  • Rudan, Igor
  • Rustichini, Aldo
  • Salomaa, Veikko
  • Sarin, Antti-Pekka
  • Schlessinger, David
  • Scott, Rodney J.
  • Snieder, Harold
  • St Pourcain, Beate
  • Starr, John M.
  • Sul, Jae Hoon
  • Surakka, Ida
  • Svento, Rauli
  • Teumer, Alexander
  • Tiemeier, Henning
  • van Rooij, Frank J. A.
  • Van Wagoner, David R.
  • Vartiainen, Erkki
  • Viikari, Jorma
  • Vollenweider, Peter
  • Vonk, Judith M.
  • Waeber, Gérard
  • Weir, David R.
  • Wichmann, H.-Erich
  • Widen, Elisabeth
  • Willemsen, Gonneke
  • Wilson, James F.
  • Wright, Alan F.
  • Conley, Dalton
  • Davey-Smith, George
  • Franke, Lude
  • Groenen, Patrick J. F.
  • Hofman, Albert
  • Johannesson, Magnus
  • Kardia, Sharon L. R.
  • Krueger, Robert F.
  • Laibson, David I.
  • Martin, Nicholas G.
  • Meyer, Michelle N.
  • Posthuma, Danielle
  • Thurik, A. Roy
  • Timpson, Nicholas J.
  • Uitterlinden, André G.
  • van Duijn, Cornelia M.
  • Visscher, Peter M.
  • Benjamin, Daniel J.
  • Cesarini, David
  • Koellinger, Philipp D.
  • Rietveld, Cornelius A.
  • Medland, Sarah E.
  • Derringer, Jaime
  • Yang, Jian
  • Esko, Tonu
  • Martin, Nicolas W.
  • Westra, Harm-Jan
  • Shakhbazov, Konstantin
  • Abdellaoui, Abdel
  • Agrawal, Arpana
  • Albrecht, Eva
  • Alizadeh, Behrooz Z.
  • Amin, Najaf
  • Barnard, John
  • Baumeister, Sebastian E.
  • Benke, Kelly S.
  • Bielak, Lawrence F.
  • Boatman, Jeffrey A.
  • Boyle, Patricia A.
  • Davies, Gail
  • de Leeuw, Christiaan
  • Eklund, Niina
  • Evans, Daniel S.
  • Ferhmann, Rudolf
  • Fischer, Krista
  • Gieger, Christian
  • Gjessing, HÃ¥kon K.
  • Hagg, Sara
  • Harris, Jennifer R.
  • Hayward, Caroline
  • Holzapfel, Christina
  • Ibrahim-Verbaas, Carla A.
  • Ingelsson, Erik
  • Jacobsson, Bo
  • Joshi, Peter K.
  • Jugessur, Astanand
  • Kaakinen, Marika
  • Kanoni, Stavroula
  • Karjalainen, Juha
  • Kolcic, Ivana
  • Kristiansson, Kati
  • Kutalik, Zoltán
  • Lahti, Jari
  • Lee, Sang H.
  • Lin, Peng
  • Lind, Penelope A.
  • Liu, Yongmei
  • Lohman, Kurt
  • Loitfelder, Marisa
  • McMahon, George
  • Vidal, Pedro Marques
  • Meirelles, Osorio
  • Milani, Lili
  • Myhre, Ronny
  • Nuotio, Marja-Liisa
  • Oldmeadow, Christopher J.
  • Petrovic, Katja E.
  • Peyrot, Wouter J.
  • PolaÅ¡ek, Ozren
  • Quaye, Lydia
  • Reinmaa, Eva
  • Rice, John P.
  • Rizzi, Thais S.
  • Schmidt, Helena
  • Schmidt, Reinhold
  • Smith, Albert V.
  • Smith, Jennifer A.
  • Tanaka, Toshiko
  • Terracciano, Antonio

Abstract

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R2 ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Suggested Citation

  • Hastie, Nicholas D. & van der Loos, Matthijs J. H. M. & Vitart, Veronique & Völzke, Henry & Wellmann, Jürgen & Yu, Lei & Zhao, Wei & Allik, Jüri & Attia, John R. & Bandinelli, Stefania & Bastardot,, 2013. "GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment," Scholarly Articles 13383543, Harvard University Department of Economics.
    • Handle: RePEc:hrv:faseco:13383543
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    References listed on IDEAS

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    1. Roland G. Fryer, 2011. "Financial Incentives and Student Achievement: Evidence from Randomized Trials," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 126(4), pages 1755-1798.
    2. Arendt, Jacob Nielsen, 2005. "Does education cause better health? A panel data analysis using school reforms for identification," Economics of Education Review, Elsevier, vol. 24(2), pages 149-160, April.
    3. B. Devlin & Kathryn Roeder, 1999. "Genomic Control for Association Studies," Biometrics, The International Biometric Society, vol. 55(4), pages 997-1004, December.
    4. James Heckman & Seong Hyeok Moon & Rodrigo Pinto & Peter Savelyev & Adam Yavitz, 2010. "Analyzing social experiments as implemented: A reexamination of the evidence from the HighScope Perry Preschool Program," Quantitative Economics, Econometric Society, vol. 1(1), pages 1-46, July.
    5. Miller, Paul & Mulvey, Charles & Martin, Nick, 2006. "The return to schooling: Estimates from a sample of young Australian twins," Labour Economics, Elsevier, vol. 13(5), pages 571-587, October.
    6. Heckman, James J. & Moon, Seong Hyeok & Pinto, Rodrigo & Savelyev, Peter A. & Yavitz, Adam, 2010. "The rate of return to the HighScope Perry Preschool Program," Journal of Public Economics, Elsevier, vol. 94(1-2), pages 114-128, February.
    7. Gunnar Isacsson, 2004. "Estimating the economic return to educational levels using data on twins," Journal of Applied Econometrics, John Wiley & Sons, Ltd., vol. 19(1), pages 99-119.
    8. David Cesarini & Christopher T. Dawes & Magnus Johannesson & Paul Lichtenstein & Björn Wallace, 2009. "Genetic Variation in Preferences for Giving and Risk Taking," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 124(2), pages 809-842.
    9. Adriana Lleras-Muney, 2005. "The Relationship Between Education and Adult Mortality in the United States," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 72(1), pages 189-221.
    10. John P A Ioannidis, 2005. "Why Most Published Research Findings Are False," PLOS Medicine, Public Library of Science, vol. 2(8), pages 1-1, August.
    11. James Heckman & Seong Hyeok Moon & Rodrigo Pinto & Peter Savelyev & Adam Yavitz, 2010. "Analyzing social experiments as implemented: evidence from the HighScope Perry Preschool Program," CeMMAP working papers CWP22/10, Centre for Microdata Methods and Practice, Institute for Fiscal Studies.
    12. Taubman, Paul, 1976. "The Determinants of Earnings: Genetics, Family, and Other Environments; A Study of White Male Twins," American Economic Review, American Economic Association, vol. 66(5), pages 858-870, December.
    13. Yona Rubinstein & James J. Heckman, 2001. "The Importance of Noncognitive Skills: Lessons from the GED Testing Program," American Economic Review, American Economic Association, vol. 91(2), pages 145-149, May.
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