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Preferences of People Living with HIV for Long-Acting Antiretroviral Treatment in Germany: Evidence from a Discrete Choice Experiment

Author

Listed:
  • Martin Emmert

    (University of Bayreuth)

  • Stefan Rohrbacher

    (University of Bayreuth)

  • Jennifer Jahn

    (GWS-Gesundheit Wissenschaft Strategie GmbH (Health-Science-Strategy Ltd.))

  • Katharina Fernando

    (GWS-Gesundheit Wissenschaft Strategie GmbH (Health-Science-Strategy Ltd.))

  • Michael Lauerer

    (University of Bayreuth
    GWS-Gesundheit Wissenschaft Strategie GmbH (Health-Science-Strategy Ltd.))

Abstract

Objective This study aimed to elicit preferences for attributes of current and novel long-acting antiretroviral therapy for human immunodeficiency virus treatment. Methods Primary survey data were collected (July–October 2022) on a sample of 333 people living with human immunodeficiency virus in Germany from a patient recruitment agency. Respondents were invited by e-mail to respond to a web-based questionnaire. After performing a systematic literature review, we conducted qualitative semi-structured interviews to identify and select the key attributes of drug therapy for patients’ preferences for human immunodeficiency virus treatment. Based on this, a discrete choice experiment survey elicited preferences for long-acting antiretroviral therapy characteristics, including the type of medication, frequency of dosing, the location of treatment, the risk of both short-term and long-term side effects, as well as possible interactions with other medications or (party) drugs. A statistical data analysis was performed using multinomial logit models. An additional latent class multinomial logit was performed to evaluate subgroup differences. Results Overall, 226 respondents (86% male, mean age 46.1 years) were included in the analysis. The frequency of dosing (36.1%) and the risk of long-term side effects (28.2%) had the greatest influence on preferences. The latent class analysis identified two patient groups. While the first class (n = 135; 87% male, mean age 44.4 years) found the frequency of dosing (44.1%) to be most important, the second class (n = 91; 85% male, mean age 48.6 years) focused on the risk of long-term side effects (50.3%). The evaluation of structural variables showed that male respondents, those living in small cities or villages, and those with better health status results were significantly more likely to be assigned to the second class (p

Suggested Citation

  • Martin Emmert & Stefan Rohrbacher & Jennifer Jahn & Katharina Fernando & Michael Lauerer, 2023. "Preferences of People Living with HIV for Long-Acting Antiretroviral Treatment in Germany: Evidence from a Discrete Choice Experiment," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 16(5), pages 537-553, September.
    • Handle: RePEc:spr:patien:v:16:y:2023:i:5:d:10.1007_s40271-023-00641-y
    DOI: 10.1007/s40271-023-00641-y
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    References listed on IDEAS

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    1. White,Halbert, 1996. "Estimation, Inference and Specification Analysis," Cambridge Books, Cambridge University Press, number 9780521574464.
    2. Greene, William H. & Hensher, David A., 2003. "A latent class model for discrete choice analysis: contrasts with mixed logit," Transportation Research Part B: Methodological, Elsevier, vol. 37(8), pages 681-698, September.
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