IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v45y2022i12d10.1007_s40264-022-01236-6.html
   My bibliography  Save this article

Prevalence, Causes and Severity of Medication Administration Errors in the Neonatal Intensive Care Unit: A Systematic Review and Meta-Analysis

Author

Listed:
  • Josephine Henry Basil

    (Universiti Kebangsaan Malaysia)

  • Chandini Menon Premakumar

    (Universiti Kebangsaan Malaysia)

  • Adliah Mhd Ali

    (Universiti Kebangsaan Malaysia)

  • Nurul Ain Mohd Tahir

    (Universiti Kebangsaan Malaysia)

  • Noraida Mohamed Shah

    (Universiti Kebangsaan Malaysia)

Abstract

Introduction Neonates are at greater risk of preventable adverse drug events as compared to children and adults. Objective This study aimed to estimate and critically appraise the evidence on the prevalence, causes and severity of medication administration errors (MAEs) amongst neonates in Neonatal Intensive Care Units (NICUs). Methods A systematic review and meta-analysis was conducted by searching nine electronic databases and the grey literature for studies, without language and publication date restrictions. The pooled prevalence of MAEs was estimated using a random-effects model. Data on error causation were synthesised using Reason’s model of accident causation. Results Twenty unique studies were included. Amongst direct observation studies reporting total opportunity for errors as the denominator for MAEs, the pooled prevalence was 59.3% (95% confidence interval [CI] 35.4–81.3, I2 = 99.5%). Whereas, the non-direct observation studies reporting medication error reports as the denominator yielded a pooled prevalence of 64.8% (95% CI 46.6–81.1, I2 = 98.2%). The common reported causes were error-provoking environments (five studies), while active failures were reported by three studies. Only three studies examined the severity of MAEs, and each utilised a different method of assessment. Conclusions This is the first comprehensive systematic review and meta-analysis estimating the prevalence, causes and severity of MAEs amongst neonates. There is a need to improve the quality and reporting of studies to produce a better estimate of the prevalence of MAEs amongst neonates. Important targets such as wrong administration-technique, wrong drug-preparation and wrong time errors have been identified to guide the implementation of remedial measures.

Suggested Citation

  • Josephine Henry Basil & Chandini Menon Premakumar & Adliah Mhd Ali & Nurul Ain Mohd Tahir & Noraida Mohamed Shah, 2022. "Prevalence, Causes and Severity of Medication Administration Errors in the Neonatal Intensive Care Unit: A Systematic Review and Meta-Analysis," Drug Safety, Springer, vol. 45(12), pages 1457-1476, December.
  • Handle: RePEc:spr:drugsa:v:45:y:2022:i:12:d:10.1007_s40264-022-01236-6
    DOI: 10.1007/s40264-022-01236-6
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-022-01236-6
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1007/s40264-022-01236-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Peter J. Gates & Melissa T. Baysari & Madlen Gazarian & Magdalena Z. Raban & Sophie Meyerson & Johanna I. Westbrook, 2019. "Prevalence of Medication Errors Among Paediatric Inpatients: Systematic Review and Meta-Analysis," Drug Safety, Springer, vol. 42(11), pages 1329-1342, November.
    2. Anwar A. Alghamdi & Richard N. Keers & Adam Sutherland & Darren M. Ashcroft, 2019. "Prevalence and Nature of Medication Errors and Preventable Adverse Drug Events in Paediatric and Neonatal Intensive Care Settings: A Systematic Review," Drug Safety, Springer, vol. 42(12), pages 1423-1436, December.
    3. Fatema A. Alqenae & Douglas Steinke & Richard N. Keers, 2020. "Prevalence and Nature of Medication Errors and Medication-Related Harm Following Discharge from Hospital to Community Settings: A Systematic Review," Drug Safety, Springer, vol. 43(6), pages 517-537, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Olive Schmid & Bonnie Bereznicki & Gregory Mark Peterson & Jim Stankovich & Luke Bereznicki, 2022. "Persistence of Adverse Drug Reaction-Related Hospitalization Risk Following Discharge," IJERPH, MDPI, vol. 19(9), pages 1-12, May.
    2. Sun-Joo Jang & Haeyoung Lee & Youn-Jung Son, 2021. "Perceptions of Patient Safety Culture and Medication Error Reporting among Early- and Mid-Career Female Nurses in South Korea," IJERPH, MDPI, vol. 18(9), pages 1-11, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:45:y:2022:i:12:d:10.1007_s40264-022-01236-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.