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Sex differences orchestrated by androgens at single-cell resolution

Author

Listed:
  • Fei Li

    (Chinese Academy of Sciences)

  • Xudong Xing

    (Peking University)

  • Qiqi Jin

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    ShanghaiTech University)

  • Xiang-Ming Wang

    (Peking University)

  • Pengfei Dai

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ming Han

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Huili Shi

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ze Zhang

    (University of Chinese Academy of Sciences)

  • Xianlong Shao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yunyi Peng

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yiqin Zhu

    (Chinese Academy of Sciences)

  • Jiayi Xu

    (Shanghai Normal University)

  • Dan Li

    (Memorial Sloan Kettering Cancer Center)

  • Yu Chen

    (Memorial Sloan Kettering Cancer Center)

  • Wei Wu

    (Fudan University)

  • Qiao Wang

    (Fudan University)

  • Chen Yu

    (Shenzhen Bay Laboratory)

  • Luonan Chen

    (Chinese Academy of Sciences
    ShanghaiTech University
    University of Chinese Academy of Sciences)

  • Fan Bai

    (Peking University)

  • Dong Gao

    (Chinese Academy of Sciences
    Shenzhen Bay Laboratory)

Abstract

Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens1–7. However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased immune gene expression and immune cell populations, such as group 2 innate lymphoid cells, were modulated by androgens. Integration with the UK Biobank dataset revealed potential cellular targets and risk gene enrichment in antigen presentation for sex-biased diseases. This study lays the groundwork for understanding the sex differences orchestrated by androgens and provides important evidence for targeting the androgen pathway as a broad therapeutic strategy for sex-biased diseases.

Suggested Citation

  • Fei Li & Xudong Xing & Qiqi Jin & Xiang-Ming Wang & Pengfei Dai & Ming Han & Huili Shi & Ze Zhang & Xianlong Shao & Yunyi Peng & Yiqin Zhu & Jiayi Xu & Dan Li & Yu Chen & Wei Wu & Qiao Wang & Chen Yu , 2024. "Sex differences orchestrated by androgens at single-cell resolution," Nature, Nature, vol. 629(8010), pages 193-200, May.
    • Handle: RePEc:nat:nature:v:629:y:2024:i:8010:d:10.1038_s41586-024-07291-6
    DOI: 10.1038/s41586-024-07291-6
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